René Angélil, husband of Céline Dion, has died, his rep confirmed exclusively to PEOPLE on Thursday.
"Rene Angelil, 73, passed away this morning at his home in Las Vegas after a long and courageous battle against cancer," the rep said in a statement. "The family requests that their privacy be respected at the moment."
Angélil, who guided Dion's career as her manager and mentor, is survived by the couple's three children – René-Charles, 14, and 5-year-old twins Nelson and Eddy – as well as Anne-Marie, Patrick and Jean-Pierre, his adult children from previous marriages.
"Mr. Angelil, 73, died of throat cancer at his home in Henderson while under the care of a physician," the Clark County Office of the Coroner/Medical Examiner said in a statement to PEOPLE.
The coroner's office added that Angélil's death was due to natural causes and no further investigation into his death was expected.
Born in Montreal, Angélil began his career as part of the Canadian pop rock group The Baronets in the 1960s. While the group had a modest number of hits, they eventually broke up and Angélil found success as a music manager.
In 1980, he discovered Dion, then 12, after she submitted a demo tape of a song she had written with her mother. He signed her shortly afterwards, mortgaging his home to pay for her debut album La Voix Du Bon Dieu.
Angélil was married twice before he wed his protégée – first to Denyse Duquette from 1966-1972, then to singer Anne Renée from 1974-1980. The music manager tied the knot with Dion in 1994.
Angélil had battled three bouts of cancer, leading Dion to put her career on hold multiple times to care for her husband's ongoing health issues. Angélil'scancer returned in 2014, following the removal of a tumor in December 2013, after previously being diagnosed with throat cancer in 1999.
"We have asked [doctors] many times, how long does he have, three weeks, three months? René wants to know," Dion said in a candid interview with USA TODAY in August. "But they say they don't know."
"I am scared of losing him, because it's bad," she told PEOPLE exclusively in March. "But I have to show myself, my husband and my kids that I'm strong and we're okay."
The "My Heart Will Go On" singer added that she promised to keep Angélil's dying wish.
"I'll say, 'You're scared? I understand. Talk to me about it' … And René says to me, 'I want to die in your arms.' Okay, fine, I'll be there, you'll die in my arms."
And the singer said she would keep a brave face until the end.
"You can have your shaking knees at the end, but when someone you love falls and needs help, it's not time to cry," she said. "Afterwards, sure. But not yet."
All 106 & Park 2014 4g 50 Cent Adele Adidjah Adidjahem Records Adidjahiem Records Adidjah Palmer Africa Agent Sasco Aidonia Aids Akon Album Alkaline Alliance Next Generation Amber Rose Apple Appleton Aquarius Aries Arrested Assassin Ati Auntie Vie Baby Baltimore Bank Beats Beenie Man Beres Hammond Beyonce Bill Cosby Bird Man Black Kat Black Mattic Bobbi Kristina Brown Bobby Shmurda Bob Marley Bogle Boom Boom Bounty Killa Bow Wow Brazil Breast Cancer Buju Banton Bushman Busy Signal Cable And Wireless Calado Cancer Cannabis Oil Capleton Capricorn Carnival Celine Dion Cham Cherine Chi Ching Ching Chickungunya Chino Chris Brown Chris Dymond Chris Martin Christopher Johnny Daley Chronixx Chuck Fenda Chug It Church Cinco Cinco Cliff-twang Club Club Oasis CNN Columbus Communications Cop Corey Todd Craig Dennis Crush Yard Cure Daggering Dance Dancehall D'Angel Dario Darkcide International Dash Productions Da'Ville Death Deep Jahi Delus Demarco Dengue Denzel Washington Deva Bratt Devin Di Dakta Devorce Digicel Dj Carique Dj Dan Perry Dj Flames Dj Frass Dj Fti Dj Gyeco Dj Khaled Dj Liquid Dj Natural Dj Nicoye Dj Nutzie Dj Pops Dj Randy Don Corleon Dosa Medicine Drake Dr Dre Dream Dream Weekend Drugs Ebola Eminem England English Entertainment Entertainment Report Event Fabian Marley Facebook Fast & Furious Fever Fifa Flexxx Flippa Mafia Flippa Moggela Florida Flow Floyd Mayweather Fontano Thompson Foota Hype French Gadaffie Gage Ganja Gay Gaza Slim Gemini Germany Glendale Gordon Grave Guiness Gullyside G Unit G-Unit Gwen Stefani Gyptian Horoscope Hype Tv Ice Iggy Azalea Ikon Instagram I Octane Ishawna I-SHENKO Ity Ellis Ity & Fancy Cat I-wayne Iyara Jaden Smith Jah Vinchi Jah Vinci Jamaica Jay Z J Diamonds Jennifer Lopez Jimmy Cliff Jmr Entertainment Jolly Kavalli Jr Daine Jr Gong Juke Boxx Records Jutc Kalado Kanye West Karrueche Khago Kibaki Kidd Kidd Kim Kardashian Kingston Kiprich Kip Rich Konshens Krazy Unit Entertainment Krush Yaad Krystal Tomlinson Lady Saw La Lewis LanMine Lauren Hill Laza Morgan Leech Leo Libra Lil Wayne Lime Jamaica Lincoln Lisa Hype Lisa Hyper Lloyd Banks London Louis Farrakhan Mariah Carey Marijuana Marvin The Beast Mavado Meek Mill Merciless Mexico Miami Micheal Phelps Microsoft Miss Ting Money Moon More Juice Family Moscow Movie Mr Vegas Mtv Munga Murder Music Narc Natural Black Navino News New York New York Times Nick Cannon Nicki Minaj Nick Simmons Ninja Kid Ninja Man No Doubt Notnice Nuclear October Olympic Olympics Omar Davis Onesty Papaya Pastor Paypal P Diddy Philadelphia Philly Pink Panther Pisces Plane Pnp Police Popcaan Port Antonio Portland Portmore Portmore Empire Potato Potential Kidd Prince Pin Prison Prodigal Son Qq Quick Cook Raine Seville Rape Rastafarian Raymond Small Rdx Reggae Sumfest Richie Spice Richie Stephens Rick Ross Ricky Trooper Rihanna R. Kelly Rodger Clarke Rohan Marley Romain Virgo Rum Bar Rum Rum Camp Rum Fire Ryno Safaree Sagitarius Sagittarius Savage School Scorpio Selectah Genius Series Sex Shabba Ranks Shaggy Shane Brown Shane O Shawn Storm Shawnte Sheba Sizzla Snoop Dogg Snoop Lion South Africa South Beach Specialist Spice Sports Ssc Sting Sumfest SunCity Supreme Promotions Suriname Swim Tami Chynn Tamoy Tamoy Ent Tanto Blacks Tarrus Riley Tattoo Taurus Tessanne Texas The Voice T.I. Tiny Tj Records TMZ Tobacco Tommy Lee Sparta Tony Matterhorn Tony Yayo Total Trey Songs Trinidad Trinkie Starr Twitter Tyga Unicorn United Kingdom United Nations United States Uruguay Usain Bolt US Embassy Virgo Visa Voicemail Vybz Kartel Water Wayne J Weed We The Best Whatsapp Whitney Houston Will Smith Windows Wing Stop Wiz Khalifa World Cup Wrenroy Smith Xs Promotions Yanique The Curvy Diva Yendi Phillipps Ymcmb Yohan Blake Young Buck Young Money Zimbabwe Zj Liquid Zj Rush Zj Sparks Zj Wah Wah